• AimGel Technology

    Do more with less steps

    Our AimGel artificial cells, composed of hydrogel, naturally degrade after expansion, eliminating the need for debeading steps. With a formulation that is chemically defined and free from animal products, they provide enhanced peace of mind.

    Self-degradable via Hydrolysis

    Our AimGel artificial cells are hydrogel-based, meaning they can degrade naturally after expansion, eliminating the need for debeading steps. They are chemically defined and animal-free, ensuring greater peace of mind.

    AimGel artificial cells present activation signals on a fluid membrane, emulating the immunological synapse and providing exceptional efficiency and cell quality.

    Higher T cell activation

    AimGel artificial cells display activation signals on a fluid membrane, mimicking the immunological synapse and delivering outstanding efficiency and cell quality.

  • Biomimectic approach for immune cell expansion and activation

    A fluid lipid coating that mimics the cell membrane enables interactions similar to those of genuine cells.

    Lipid Membrane Coating

    A fluid lipid coating mimicking the cell membrane enables cell-like interactions.

    A hydrogel core designed with adjustable size and softness to replicate the texture of authentic cells.

    Hydrogel Core

    A hydrogel core with variable size and softness to mimic the texture of real cells.

    Combine the necessary surface signals tailored for your specific cell type for optimal results.

    Surface Signals

    Mix and match the required combinations of surface signals optimised for your cell type.

  • Protocols

    Resources

    Step-by-step guide in using AimTconv for T cell expansion and activation.

  • Conference Posters

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    ISCT Europe Conference 2024, Gothenburg, Sweden

     

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    Singapore Cell & Gene Therapy Pan Asia Summit 2024, Singapore

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    ISCT Annual Conference 2024, Vancouver, Canada

  • Journal Publications

    1. Chung JT & Chau Y. (2023). Self-adjuvanted L-arginine modified dextran-based nanogel for sustained local antigenic protein delivery to antigen presenting cells and enhanced cellular and humoral immune responses. (under review)
    2. Chung JT, Lau CML, Chung CH, Rafiei M, Yao S & Chau Y. (2023). Vaccine delivery by zwitterionic polysaccharide-based hydrogel microparticles showing enhanced immunogenicity and suppressed foreign body responses. Biomaterials Science, 11(14), 4827-4844.
    3. Jahanmir G, Lau CML, Yu Y & Chau Y. (2022). Stochastic Lattice-Based Modeling of Macromolecule Release from Degradable Hydrogel. ACS Biomaterials Science & Engineering, 8(10), 4402-4412.
    4. Chung JT, Lau CML & Chau Y. (2021). The effect of polysaccharide-based hydrogel on the response of antigen presenting cell line to immunomodulators. Biomaterials Science 9.19 (2021): 6542-6554.
    5. Chung CHY, Lau CML, Sin DT, Chung, JT, Zhang Y, Chau Y & Yao S. (2021). Droplet-Based Microfluidic Synthesis of Hydrogel Microparticles via Click Chemistry-Based Cross-Linking for the Controlled Release of Proteins. ACS Applied Bio Materials, 4(8), 6186-6194.
    6. Lau CML, Jahanmir G, Yu Y & Chau Y. (2021). Controllable multi-phase protein release from in-situ hydrolyzable hydrogel. Journal of Controlled Release, 335, 75-85.
    7. Jahanmir G, Lau CML, Abdekhodaie MJ & Chau, Y. (2020). Dual-Diffusivity Stochastic Model for Macromolecule Release from a Hydrogel. ACS Applied Bio Materials, 3(7), 4208-4219.
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