AimGel Human NK Cell Activator
Human NK cell activation with cell-sized hydrogel microparticles
AimGel Human NK Cell Activator
$380.00
ANK01-0050H | Research Use Only
AimGel Human NK Cell Activator presents NK activating signals on soft hydrogel microparticles built to the size of a real NK cell (7-12 µm). The fluid lipid membrane lets those signals move freely across the surface, the way they do on a natural antigen-presenting cell. Activation is gentle and effective. Feeder-free, chemically defined, with no animal components.
1 vial, 0.5 mL in PBS at 4 × 10⁷ microparticles/mLQuantityData
Compatibility with existing media
Isolated NK cells expanded in two commercial NK media (Brand T & Brand M), with and without AimGel, and with a commercial magnetic bead kit (Brand M). Adding AimGel raised expansion roughly three-fold over medium alone at both timepoints, and outperformed the magnetic bead kit. Mean ± SD, n=4. * p<0.05, ** p<0.01, *** p<0.001.
Activation and re-stimulation
NK cells activated with AimGel in a commercial NK medium (Brand T), re-stimulated at day 14, and followed for a further two weeks. AimGel-activated cells continued expanding after re-stimulation; cells in medium alone peaked and then declined.
Cytotoxic effects
Cytotoxic activity of expanded NK cells against K562 target cells at effector-to-target ratios of 2:1 and 4:1. AimGel-expanded cells lysed targets as effectively as cells grown in medium alone, despite the substantially larger population.
Degradation toxicity
AimGel beads, as well as the degradation products showed excellent biocompatibility and minimum cytotoxicity at working dosage, regardless of the degradation method: hydrolysis (self-degradation), enzymatic (user-triggered via lysis buffer).
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